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Retinoid‐related orphan receptor gamma (RORγ) directly controls the differentiation of Th17 cell and the production of interleukin‐17, which plays an integral role in autoimmune diseases. To obtain insight into RORγ, we have determined the first crystal structure of a ternary complex containing RORγ ligand‐binding domain (LBD) bound with a novel synthetic inhibitor and a repressor peptide, 22‐mer...
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