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By studying the structural similarity of analgesic imidazolines and 2-phenylnitronyl nitroxides, 20 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines (2a–t) were newly synthesized as selective antagonists of prostacyclin receptor (IP receptor). In the in vivo tail-flick assay, 2a–t (dose, 0.13mmol/kg) receiving mice showed increased pain thresholds ranging from 20.52±7.25% to 90.94±11...
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