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Transforming growth factor‐â (TGF‐â) signalling plays a key role in colorectal cancer (CRC). Bone morphogenetic protein‐4 (BMP4) is a member of the TGF‐â family of signal transduction molecules. To examine if germline mutation in BMP4 causes CRC we analysed 504 genetically enriched CRC cases (by virtue of early‐onset disease, family history of CRC) for mutations in the coding sequence of BMP4. We...
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