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Freshly isolated human monocytes transport l-arginine mostly through a sodium independent, NEM insensitive pathway inhibited by l-leucine in the presence, but not in the absence of sodium. Interferon-γ (IFNγ) stimulates this pathway, identifiable with system y + L, and markedly enhances the expression of SLC7A7, the gene that encodes for system y + L subunit y+LAT1, but not of SLC7A6,...
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