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Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT 4 agonist and 5-HT 3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.
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