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Ligand binding to the α-subunit of the α 2 β 2 complex of tryptophan synthase induces the αloop6 closure over the α-active site. This conformational change is associated with the formation of a hydrogen bond between αGly181 NH group and βSer178 carbonyl oxygen, a key event for the triggering of intersubunit allosteric signals. Mutation of βSer178 to Pro and αGly181 to Pro, Ala, Phe...
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