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The RSK family (RSK1–4) is a group of highly conserved Ser/Thr kinases that act as the major downstream effectors of the Ras/Raf/MEK/ERK signaling pathway.The RSKs phosphorylate a range of substrates involved in transcription, translation, cell cycle control, and cell survival.Although the RSKs have high sequence homology, the individual RSK isoforms can promote distinct biological functions through...
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