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Preclinical data suggests that P2Y 1 antagonists, such as diarylurea compound 1, may provide antithrombotic efficacy similar to P2Y 12 antagonists and may have the potential of providing reduced bleeding liabilities. This manuscript describes a series of diarylureas bearing solublizing amine side chains as potent P2Y 1 antagonists. Among them, compounds 2l and 3h had improved...
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