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The interaction between immobilized plasminogen or an elastase-degradation product from plasminogen, constituting “kringles” 1–3 and different purified variants of antiplasmin has been studied by surface plasmon resonance utilising a BIAcore. The antiplasmin variants studied are wild-type, K429E, K436E, E443G, D444G, K452E and K452T. It is shown that the two mutants K452T and K452E react in quite...
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