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Hard clams (HC), Meretrix lusoria are a popular seafood and traditionally used as a Chinese remedy for liver disease and chronic hepatitis. The goal of this study was to identify compounds from hard clam, which are responsible for inducing apoptosis using bioassay-directed isolation. The effects of ethyl acetate extract of HC (HC-EA) on cell viability in human cancer cells were investigated. The ethyl...
Apoptosis-induced directed fractionation and purification was used to identify the bioactive components of hard clams (HC), Meretrix lusoria. Two stereoisomers of epidioxysterol were previously identified as the active compounds in the ethyl acetate fraction (HC-EA). The molecular mechanism of HC-EA-induced apoptosis was also investigated in this study. Dissipation of mitochondrial membrane potential,...
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