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We investigated the activities, both in vitro and ex vivo, of the water-soluble vitamin analogue Trolox in a model of isolated heart ischaemia–reperfusion and we compared them with those of α -tocopherol. Isolated rat hearts were perfused with Krebs–Henseleit solution. For in vitro experiments, the hearts were perfused with Trolox (20 μ mol l −1) and were subsequently subjected to 20 min of global...
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