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Pescadillo (PES1) is a key molecule for ribosome formation in mammalian cells. In this study, human hepatoma C3A cells were reprogrammed by four transcription factors, Oct4, Sox2, Klf4 and c‐Myc, into induced cancer stem cells, termed C3A‐induced cancer stem cells (C3A‐iCSCs). We found that PES1 was up‐regulated in C3A‐iCSCs and promoted cell proliferation. Moreover, the cancer stem cell marker CD44,...
A novel starch-binding domain (SBD) that represents a new carbohydrate-binding module family (CBM69) was identified in the α-amylase (AmyP) of the recently established alpha-amylase subfamily GH13_37. The SBD and its homologues come mostly from marine bacteria, and phylogenetic analysis indicates that they are closely related to the CBM20 and CBM48 families. The SBD exhibited a binding preference...
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