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ObjectiveTo establish a new animal model in DRB1*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII259–273 epitope in the induction and breaking of tolerance of DR4‐restricted T cells, and to characterize DR4‐restricted T cell recognition...
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