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The recently proposed proportional win‐fractions (PW) model extends the two‐sample win ratio analysis of prioritized composite endpoints to regression. Its proportionality assumption ensures that the covariate‐specific win ratios are invariant to the follow‐up time. However, this assumption is strong and may not be satisfied by every covariate in the model. We develop a stratified PW model that adjusts...
The win ratio is gaining traction as a simple and intuitive approach to analysis of prioritized composite endpoints in clinical trials. To extend it from two‐sample comparison to regression, we propose a novel class of semiparametric models that includes as special cases both the two‐sample win ratio and the traditional Cox proportional hazards model on time to the first event. Under the assumption...
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