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Escherichia coli oligoribonuclease (EcoORN), encoded by the orn gene, is a 3′–5′ exonuclease that degrades short single-stranded oligoribonucleotides to rNMPs in the final step of RNA degradation. The orn gene is essential in E. coli, but not in higher organisms, and close homologues are present in other genomes from the β and γ subdivisions of the Protobacteriaceae, including many pathogenic species...
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