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Pedal to the metal: The catalyst‐free Diels–Alder cycloaddition of trans‐cyclooctene and tetrazine was used to quickly and selectively generate an 18F‐labeled AZD2281 derivative from a tetrazine‐linked precursor. The probe was tested in biological assays, and its targeted accumulation was confirmed in vivo. This protocol allows the parallel synthesis of a library of potential PET imaging agents in...
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