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The direct fermentative production of l-serine using Corynebacterium glutamicum from renewable biomass attracts increasing attention. This study was designed to enhance l-serine production in a wild-type C. glutamicum SYPS-062 by using random mutagenesis, optimization of media, and metabolic engineering. The resulting mutant, C. glutamicum SYPS 062-33a, accumulated 65.4% more l-serine (11.0±0.25g/L)...
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