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Novel oxazolonaphthalimide hydroperoxides 2 and 3 have been designed, synthesized and shown to be very efficient in photocleavage of DNA by the plazmid nicking assay. The absorption and fluorescence properties of these compounds and their relevant intermediates are discussed. An explanation for the higher DNA-cleavage efficiency of these oxazole-conjugated naphthalimide hydroperoxides than the nonsubstituted...
Novel fluorine-containing hydroperoxides of oxazolonaphthalimide were designed and synthesized. The interactions of these compounds with DNA were studied.
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