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Objectives
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated and overexpressed in many cancers, including non–small‐cell lung cancer (NSCLC). We recently developed HJC0152 as an orally active STAT3 inhibitor. This study focused on investigating HJC0152's effect and mechanism of action in NSCLC.
Materials and methods
We analysed cell proliferation by MTT assays,...
Objectives
Present evidence has suggested that large tumour suppressor 2 (LATS2) is abnormally expressed in most human cancer. However, the clinical and prognostic value in hepatocellular carcinoma (HCC) is still unknown.
Materials and methods
Large tumour suppressor 2 mRNA and protein expression levels in HCC tissues and cell lines were detected by qRT‐PCR, immunohistochemistry or Western blot...
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