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Background/Objectives
Antibody detection is commonly used for diagnosis of histoplasmosis, and cross‐reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross‐reactions in an anti‐Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross‐reactive anti‐Histoplasma...
Antigen detection is a useful adjunct for the diagnosis of histoplasmosis. The purpose of this study was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83.3%) blastomycosis cases using the second-generation assay vs. 13 of 19 (68%) and 4 of...
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