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A series of novel thermo-responsive hydrogels cross-linked by acid-degradable trehalose diacetals with VPTTs tailored to biologically useful temperatures were obtained by copolymerization of Nisopropylacrylamide with more hydrophilic comonomers: acrylamide, N-(2-hydroxyethyl)acrylamide or N,N-dimethylacrylamide. Due to the properties of the acetal bond, these hydrogels degraded via acid-catalyzed...
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