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Key points
The spinal alpha motoneuron is the only cell in the human CNS whose discharge can be routinely recorded in humans.
We have reengineered motor unit collection and decomposition approaches, originally developed in humans, to measure the neural drive to muscle and estimate muscle force generation in the in vivo cat model.
Experimental, computational, and predictive approaches are used to...
Non‐technical summary Clonidine, a noradrenaline‐like drug, facilitates the recovery of hindlimb walking in adult cats following a complete spinal cord injury.We show that clonidine improves operation of reflex pathways that coordinate bilateral hindlimb activity in cats after spinal cord injury. In addition, sensory signals from the periphery more easily activate the spinal network involved in producing...
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