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There is a great potential of gelatin to be applied in food packaging, tissue engineering, and drug delivery due to its biocompatibility, edibility and biodegradability. However, the main issue with use of native gelatin based materials in practical application is their water solubility and poor thermostability as they are rapidly dissolved in warm solution. In order to improve their water-resistant...
An innovative approach to enhance the selectivity of matrix metalloproteinase (MMP) inhibitors comprises targeting these inhibitors to catalytically required substrate binding sites (exosites) that are located outside the catalytic cleft. In MMP-2, positioning of collagen substrate molecules occurs via a unique fibronectin-like domain (CBD) that contains three distinct modular collagen binding sites...
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