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EWS is a member of the FET family of RNA/DNA binding proteins that regulate crucial phases of nucleic acid metabolism. EWS comprises an N‐terminal low‐complexity domain (LCD) and a C‐terminal RNA‐binding domain (RBD). The RBD is further divided into three RG‐rich regions, which flank an RNA‐recognition motif (RRM) and a zinc finger (ZnF) domain. Recently, EWS was shown to regulate R‐loops in Ewing...
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