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Despite the known specific mediator-related effects of retinoic acid (RA), details of irritant effects of RA on the stratum corneum (SC) remain limited. This study investigates the clinical and functional changes in SC of 6 healthy volunteers induced by 0.05% and 0.1% RA in a 24 h occlusive patch-test as well as in a 10 day open cumulative test-assay compared with 1% sodium lauryl sulfate (SLS)....
Scaling caused by exfoliative agents has been though to be a sign of an increase in epidermal cell renewal. To check this suggestion, we determined the changes in stratum corneum turnover time (SCTT) in 6 healthy volunteers following a 10 day open cumulative application of 12% glycolic acid (GA), 0.1%all-trans retinoic acid (PA), 0.005% calcipotriol (CAL), and 1% SLS. SCTT was assessed by the dansyl...
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