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This study investigated the expression of nNOS after repeated morphine or cocaine administration in order to determine if nNOS (neuronal nitric oxide synthase) is involved in the morphine- or cocaine-induced behavioral sensitization in μ-opioid receptor knockout (MOR −/− ) mice. Higher numbers of nNOS-positive cells were observed in the dentate gyrus of the hippocampus (DG) of the wild-type...
To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in μ-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, thus suggesting that...
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