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Maleic acid (MA) was purposefully adulterated in an array of starch-based foods in Taiwan, inciting a food safety incident. Due to limited data on the pharmacokinetics and bioavailability of ingested MA, we studied pharmacokinetic (PK) parameters in serum and urine of Sprague Dawley rats. Three groups of male and female rats were given three doses of MA by oral gavage; biofluid samples were collected...
A rapid and simple on-line solid-phase extraction coupled with isotope dilution–liquid chromatography–tandem mass spectrometry (SPE–ID–LC–MS/MS) method was developed to quantitate maleic acid in serum and urine of SpragueDawley (SD) rats. The aforementioned biological samples were spiked with 13 C 2 -maleic acid, vigorously vortexed, added with acetonitrile to precipitate proteins,...
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