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Safrole (1) is a natural product found in herbs and spices. Upon uptake, it can be metabolized to safrole 2′,3′‐oxide [(±)‐SFO, 2], which can react with DNA bases to form DNA adducts. The reactions of 2 with 2′‐deoxyadenosine (3) and adenine (8) under physiological conditions (pH 7.4, 37 °C) were carried out to characterize its possible adducts with adenine. Four adducts were isolated by reverse‐phase...
Dose-response relationships of genotoxic agents differ greatly depending on the agent and the endpoint being evaluated. Simple conclusions that genotoxic effects are linear cannot be applied universally. The shape of the molecular dose of DNA adducts varies from linear, to supralinear, to sublinear depending on metabolic activation and detoxication, and repair of individual types of DNA adducts. For...
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