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Temporal lobe epilepsy is associated with dysfunctional brain networks. Here we investigated metabolic connectivity in the pilocarpine-induced epilepsy rat model and applied a new multiscale framework to the analysis of metabolic networks of small-animal brains. [18F]fluorodeoxyglucose PET was acquired in pilocarpine-induced chronic epilepsy rats and controls to yield interregional metabolic correlation...
To localize epileptogenic zones, preoperative evaluation of surgical candidates by F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) has become a routine practice. Among 118 who were operated for medial temporal and neocortical epilepsies and followed up for more than a year, the sensitivity of FDG PET was 85%. In contrast, the sensitivity of MRI or ictal SPECT was only 75%. FDG...
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