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l-Leucine formed different crystalline coatings on salbutamol sulphate aerosol particles depending on the saturation conditions of l-leucine. The work emphasizes a careful characterization of powders where structural compartments such as crystal size and particle coating may affect the performance of drug when administered. The sublimation of l-leucine from the aerosol particles took place 90°C lower...
The sublimation kinetics of amino acid l-leucine is studied with the isothermal thermogravimetric (TG) analysis at temperatures between 400.7 and 517.5K. Sublimation of l-leucine follows zero order kinetics. l-leucine begins to sublime around 423.2K and sublimation rate increases exponentially with increasing temperature. The vapour pressure of l-leucine is determined based on the mass loss rate showing...
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