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l-Leucine formed different crystalline coatings on salbutamol sulphate aerosol particles depending on the saturation conditions of l-leucine. The work emphasizes a careful characterization of powders where structural compartments such as crystal size and particle coating may affect the performance of drug when administered. The sublimation of l-leucine from the aerosol particles took place 90°C lower...
Purpose The crystallization and structural integrity of micron-sized inhalable salbutamol sulphate particles coated with l-leucine by different methods are investigated at different humidities. The influence of the l-leucine coating on the crystallization of salbutamol sulphate beneath the coating layer is explored. Methods The coated particles are prepared by an aerosol flow reactor method, the...
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