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Background This study aims to further evaluate the specificity and selectivity of [18F]FTC-146 and obtain additional data to support its clinical translation. Methods The binding of [19F]FTC-146 to vesicular acetylcholine transporter (VAChT) was evaluated using [3H]vesamicol and PC12A123.7 cells in an in vitro binding assay. The uptake and kinetics of [18F]FTC-146 in S1R-knockout mice (S1R-KO) compared...
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