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Deposition of β-amyloid protein in the brain is a neuropathological hallmark of Alzheimer's disease. An additional feature of this disease is an upregulation of the lysosomal system, however, the role of lysosomal proteins in the pathogenesis of this neurodegenerative condition is unclear. In this study, we demonstrate that Aβ increases activity of the lysosomal protease, cathepsin-L, and promotes...
β-Amyloid (1-40) -induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. β-Amyloid protein is thought to contribute to the pathophysiology of Alzheimer's disease by inducing neuronal apoptosis. Our previous work has demonstrated that β-amyloid activates voltage-dependent Ca 2+ channels in the cortex,...
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