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Novel methyl 2-hydroxy-5-substituted benzoate derivatives (2a–2i) were synthesized by esterification of methyl gentisate and long-chain fatty acids. The compounds were structurally confirmed by MS, IR, 1H NMR, and HR-MS spectroscopy. A preliminary bioassay test demonstrated that compounds 2b, 2c, 2f, 2g, 2h showed stronger inhibition of tyrosinase activity. Further pharmacological experiments showed...
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