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Age-related bone loss in humans is associated with a decrease in bone formation relative to bone resorption, although the mechanisms for this impairment in bone formation with aging are not well understood. It is known that the precursors for the bone-forming osteoblasts reside in the mesenchymal cell population in bone marrow. Thus, in an effort to identify relevant genetic pathways that are altered...
Although aging is associated with a decline in bone formation in humans, the molecular pathways contributing to this decline remain unclear. Several previous clinical studies have shown that circulating sclerostin levels increase with age, raising the possibility that increased production of sclerostin by osteocytes leads to the age-related impairment in bone formation. Thus, in the present study,...
This study was undertaken to investigate the age‐related differences of monocyte chemotactic protein‐1 (MCP‐1) and matrix metalloproteinase‐3 (MMP‐3) expression in mouse intervertebral disc (IVD) and to determine whether MMP‐3 plays a role in disc degeneration. Expression of MCP‐1 and MMP‐3 mRNA in mouse IVD was assessed by quantitative PCR. The ability of MCP‐1 and MMP‐3 expression in IVD to respond...
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