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This study introduces a novel texture analysis scheme applied to perfusion volumes in dynamic contrast-enhanced (DCE) breast MRI to provide a method of lesion discrimination. DCE MRI was applied to 24 lesions (12 malignant, 12 benign). Automatic segmentation was performed for extraction of a lesion volume, which was divided into whole, rim and core volume partitions. Lesion perfusion volumes were...
A simple, label-free microfluidic separation of cancer cells by exploiting difference in cell adhesion. To maximize the adhesion difference, three types of polymeric nanostructures (50 nm pillars, 50 nm perpendicular and parallel lines with respect to the direction of flow) were fabricated using UV- assisted capillary moulding onto glass substrate of PDMS microfluidic channel. The adhesion force of...
We introduced a droplet-based magnetically activated cell separator (DMACS) that utilizes a hanging droplet of microliter-sized volume for dividing positive (magnetically labeled) and negative (magnetically unlabeled) cells. It enabled us to solve adhesion problem in channel and showed better separation efficiency. However, the separation efficiency was changed under variations of initial volume (the...
We have introduced well-defined nanopillar arrays of polyethylene glycol (PEG) as a platform for studying the adhesion and growth of cultured cardiomyocytes. The nanopillar arrays were fabricated by using a simple molding technique involving the placement of a patterned polyurethane acrylate mold on top of a drop-dispensed ultraviolet (UV) curable PEG polymer followed by UV exposure and mold removal...
A microrobotic force sensing system is used to characterize the mechanical properties of the chorion of zebrafish embryos and quantitate the mechanical property differences of the chorion at different developmental stages. Quantitative relationships between applied forces and chorion structural deformations are established for various developmental stages. The measured penetration forces for puncturing...
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