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Hot dog fold proteins sharing the characteristic “hot dog” fold are known to involve certain coenzyme A binding enzymes with various oligomeric states. In order to elucidate the oligomerization–function relationship of the hot dog fold proteins, crystal structures of the phenylacetate degradation protein PaaI from Thermus thermophilus HB8 (TtPaaI), a tetrameric acyl-CoA thioesterase with the hot dog...
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