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The eukaryotic proteasome is a 26S ATP-dependent proteolytic complex, which possesses chymotrypsin-like, trypsin-like and peptidyl glutamyl peptide hydrolase (PGPH) activities, which enable the proteasome to degrade all short-lived and many long-lived proteins, and consequently regulate a myriad of activities in cells. In this study, we observed that inhibition of the proteasome, and more specifically,...
Treatment of cells with estrogens and several pure ERα antagonists rapidly induces down-regulation of the α-type estrogen receptor (ERα) in the nucleus by mechanisms that are sensitive to the proteasome inhibitors, MG132 and clasto-lactacystin-β-lactone. Hence, it is believed that these ER ligands induce down-regulation of ERα by proteasome-dependent mechanisms, which serve to control both the amount...
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