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Tumor mutational burden (TMB) assessment is at the forefront in precision medicine. The TMB could represent a biomarker for immune checkpoint inhibitors (ICIs) responses. Whole exome sequencing (WES) is the gold standard to derive the TMB; while targeted next-generation sequencing panels might be more feasible. However, mainstream panels use ‘correlation’ (R2) between panel- and WES-based TMB to validate...
Motion errors are inevitably introduced when data are acquired and considerably degrade the image quality in terms of geometric resolution, radiometric accuracy and image contrast, especially in high resolution spotlight synthetic aperture radar (SAR) imagery. In this paper, we describe a weighted contrast enhancement autofocus algorithm that is based on spatially variant model and adopts a mean square...
Gestures contain enough information to distinguish a person from another. This ‘biometric’ feature is the basis of the Kinect-enabled system described in this paper, which is designed to identify a given person through a short chain of in-air gestures (2–3 ones). The user-dependent (trainable) system relies on a traditional Dynamic Time Warping classification algorithm. This core algorithm enhances...
This research describes an integrated multi-channel high accuracy current control LED driver with low dropout regulator implemented in a 0.35um TSMC 2P4M CMOS process. With the new trend of backlighting applications for mobile electronics and portable devices requiring a smaller size, lower cost, lesser noise and accurate current control LED driver, it came up with the idea of integrating more than...
Fisher's linear discriminant analysis (FLDA) is one of the most well-known linear subspace selection methods. However, FLDA suffers from the class separation problem. The projection to a subspace tends to merge close class pairs. Recent results show that maximizing the geometric mean or harmonic mean of Kullback-Leibler (KL) divergences of class pairs can significantly reduce this problem. In this...
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