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S. C. Heilshorn and co‐workers design shear‐thinning hydrogels for injectable encapsulation and long‐term delivery (SHIELD) by combining protein‐engineering and synthetic polymer technologies. On page 1344, stem cell transplantation using SHIELD results in a 400% increase in one‐week cell retention compared to cell delivery in saline, the clinical standard. These materials work by providing a “shield”...
Stem cell transplantation via direct injection is a minimally invasive strategy being explored for treatment of a variety of injuries and diseases. Injectable hydrogels with shear moduli <50 Pa can mechanically protect cells during the injection process; however, these weak gels typically biodegrade within 1–2 weeks, which may be too fast for many therapeutic applications. To address this limitation,...
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