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The yeast Saccharomyces cerevisiae gene CCH1 (ORF YGR217w) shows high homology with animal calcium channel α1-subunit genes. Knock-out mutants were constructed of Cch1 and of Mid1 which is known to mediate Ca 2+ influx in response to the α-mating pheromone. Cch1 is involved in calcium influx and the late stage of the mating process. The cch1 mutant sensitivity against the α-mating pheromone...
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