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With a half-time of 78 million years at room temperature, the spontaneous decarboxylation of orotidine 5′-phosphate (OMP) is among the slowest biological reactions to be described. Orotidine 5′-phosphate decarboxylase (ODCase), the enzyme responsible for catalyzing this difficult transformation, performs its task without the assistance of metals or small molecule cofactors. The crystal structures...
With a half-time of 78 million years at room temperature, the spontaneous decarboxylation of orotidine 5′-phosphate (OMP) is among the slowest biological reactions to be described. Orotidine 5′-phosphate decarboxylase (ODCase), the enzyme responsible for catalyzing this difficult transformation, performs its task without the assistance of metals or small molecule cofactors. The crystal structures...
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