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Changes in PMCA2 and PMCA3 expression during neuronal development are tightly linked to structural and functional modifications in Ca 2+ handling machinery. Using antisense strategy we obtained stably transfected PC12 lines with reduced level of PMCA2 or PMCA3, which were then subjected to dibutyryl-cAMP differentiation. Reduced level of neuron-specific PMCAs led to acceleration of differentiation...
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