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We have characterized the viral RNA conformation in wild-type, protease-inactive (PR – ) and SL1-defective (ΔDIS) human immunodeficiency virus type 1 (HIV-1), as a function of the age of the viruses, from newly released to grown-up (≥24 h old). We report evidence for packaging HIV-1 genomic RNA (gRNA) in the form of monomers in PR – virions, viral RNA rearrangement (not maturation)...
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