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The IgG of a monoclonal antibody N34 specific for urokinase and the Fab fragment of a monoclonal antibody specific for the granule membrane protein GMP-140 of activated platelet were chemically cross linked by disulfide bond. The coupled bispecific antibody (N34-SZ-51) was able to bind urokinase and plasma clot simultaneously. The bispecific antibody enhanced plasma clot lysis by high molecular...
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