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Pyrrolysyl-tRNA synthetase (PylRS) esterifies pyrrolysine to tRNA Pyl . In this study, N ɛ -(tert-butyloxycarbonyl)-L-lysine (BocLys) and N ɛ -allyloxycarbonyl-L-lysine (AlocLys) were esterified to tRNA Pyl by PylRS. Crystal structures of a PylRS catalytic fragment complexed with BocLys and an ATP analog and with AlocLys-AMP revealed that PylRS requires an N ɛ ...
SWIRM is an evolutionarily conserved domain involved in several chromatin-modifying complexes. Recently, the LSD1 protein, which bears a SWIRM domain, was found to be a demethylase for Lys4-methylated histone H3. Here, we report a solution structure of the SWIRM domain of human LSD1. It forms a compact fold composed of 6 α helices, in which a 20 amino acid long helix (α4) is surrounded by 5 other...
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