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The melastatin-related transient receptor potential channel TRPM2 is a Ca 2+ -permeable channel that is activated by H 2 O 2 , and the Ca 2+ influx through TRPM2 mediates cell death. However, the responsible oxidants for TRPM2 activation remain to be identified. In the present study, we investigated the involvement of hydroxyl radical on TRPM2 activation in TRPM2-expressing...
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