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Eukaryotic neurotransmitter:sodium symporters (NSSs), targets for antidepressants and psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal structure of LeuT Aa , a prokaryotic NSS homolog, revealed an occluded state in which one leucine and two Na + ions are bound, but provided limited clues to the molecular mechanism of transport. Using steered molecular...
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