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The claim by Nelson et al. (2001) that the reactionof cyanoacetaldehyde and urea provides `an efficient prebioticsynthesis' of cytosine is disputed. The authors have not dealt withthe important points presented in a criticism of this reaction(Shapiro, 1999): (1) The reactants undergo side reactions with commonnucleophiles that appear to proceed more rapidly than cytosineformation, and (2) No reactions...
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