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Ryanodine receptors (RyRs) are large tetrameric calcium (Ca 2+ ) release channels found on the sarcoplasmic reticulum that respond to dihydropyridine receptor activity through a direct conformational interaction and/or indirect Ca 2+ sensitivity, propagating sarcoplasmic reticulum luminal Ca 2+ release in the process of excitation–contraction coupling. There are three human...
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